A2ML1 Polyclonal Antibody - E-AB-91925

A2ML1 Polyclonal Antibody Sizes: 60μL, 120μL, 200μL Catalogue Numbers: E-AB-91925-60, E-AB-91925-120, E-AB-91925-200 Citations, Manuals and MSDS Available upon request. Abbreviation: A2ML1 Target Synonym: CPAMD9; p170; A2ML1 Conjugation: Unconjugated Host: Rabbit Species Reactivity: Human, Rat Application: WB Isotype: IgG Clonality: Polyclonal UNIProt ID: A8K2U0 Background: This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript va