ABCE1 Rabbit Monoclonal Antibody-MB66263

ABCE1 Rabbit Monoclonal Antibody Catalogue Numbers: MB66263-50, MB66263-100 Sizes: 50µl, 100µl Product: Liquid in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA. Swiss-Prot: P61221 Host: Rabbit Reactivity: Human, Mouse, Rat Applications: WB, IP All Applications: WB (1/500 - 1/1000), IP (1/10 - 1/50) Background: ABCE1 (RNS4I, RLI) is a mediator of the 2-5A/RNase L pathway. The 2-5A/RNase L system is considered an essential pathway of interferon (IFN) action. In the pathway, IFN stimulation activates 2-5A synthetases which convert ATP into a set of atypical oligomers known as 2-5A. These oligomers in turn activate RNase L (RNS4), which leads to inhibition of protein synthesis by cleaving mRNAs at the 3-prime side of UpNp sequences. This inhibition necessitates the association of ABCE1 with RNase L and is dependent on the ratio between the two proteins. The 2-5A/RNase L system could also play a more general physiological role, for instance,