ACC1 Polyclonal Antibody-BS90018

ACC1 Polyclonal Antibody Sizes: 50µl, 100µl Catalogue Numbers: BS90018-50, BS90018-100 Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Swiss-Prot: Q13085 Human;Q5SWU9 Mouse;P11497 Rat Host: Rabbit Reactivity: Human, Mouse, Rat Applications: WB, ICC IHC FC All Applications: WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 Background: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and