Metabolism Support

Thiamin activates glyceraldehyde phosphate dehydrogenase (GAPDH). Decreased availability of this enzyme has been implicated in diabetes complications such as blindness, nerve damage, kidney failure, stroke and cardiovascular disease.Thiamin repletion in the case of a six year-old girl with diabetes caused by a genetic mutation effecting thiamine transport demonstrated its benefits. Thiamin deficiency may cause diabetic neuropathy by decreasing transketolase, needed for normal myelinization and thiamine monophasphatase, needed for primary sensory neuron function.*Niacin is required for lipid metabolism, tissue respiration and glycogenolysis. It may preserve and protect Beta cells. Niacinamide improved insulin secretion in lean diabetics who had failed drug treatment.*[5] Chromium and Biotin synergistically improve glucose tolerance.Biotin, in large doses (5-15 mgs) enhances the effects of enzymes involved in glucose metabolism. One small study demonstrated reversal of diabetic neuropath