SARS-CoV-2 Spike Glycoprotein ACE2 MOA 6VXX-6M17

Spike Glycoprotein 6VXX-6M17 depicts 'RBD-Up' state of the Spike when bound to ACE2 Receptor.  Following ACE2 binding, the top of the Spike Glycoprotein detaches. This mechanism-of-action Biologic Model demonstrates this cause-effect interaction by detaching the SD1 domain from the core SD2 stalk.  Model Description Biologic Model of SARS-CoV-2 Spike Glycoprotein 6VXX 3D printed and colored coded to match SCIENCE publication denoting Spike functional domains (NTD blue, RBD green, SD1, light tan, SD2 red-orange-yellow, FP cyan, RRAR brown) and ACE2 Receptor (pink).