PD173074

PD173074 (219580-11-7) is an inhibitor of FGFR tyrosine kinase, and to a lesser extent VEGFR1 (IC50 values are 5 nM, 22.5 nM and 100 nM for FGFR1, FGFR3 and VEGFR respectively). Inhibition of FGFR by PD173074 promotes stem cell self renewal.2,3 References/Citations: 1 Bansal et al. (2003), Specific inhibitor of FGF receptor signaling: FGF-2 mediated effects on proliferation, differentiation and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells; J. Neurosci. Res., 74 4862) Kim et al. (2012), Regulation of autocrine fibroblast growth factor-2 signaling by perfusion flow in 3D human mesenchymal stem cell constructs; Biotechnol. Prog., 28 13843) Zaragosi et al. (2006), Autocrine fibroblast growth factor 2 signaling is critical for self renewal of human multipotent adipose-derived stem cells; Stem Cells, 24 2412 CAS: 219580-11-7 Catalog Number: 10-4505 Activity: FGFR inhibitor Chemical Name: 1-t-Butyl-3-(6-(3,5-dimethoxyphenyl)-2-(4-diethylaminobutyl