Ro 415253

Ro 41-5253 (144092-31-9) is a selective RARα antagonist.1 Binds RARα without inducing transcription or influencing RAR/RXR heterodimerization and DNA binding.2 Ro 415253 inhibits proliferation and induces apoptosis in a variety of cell lines/types. Cell Permeable. References/Citations: 1) Apfel et al. (1992), A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects; Proc. Natl. Acad. Sci. USA, 89 71292) Toma et al. (1998), RARα antagonist Ro 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines; Int. J. Cancer, 78 86 CAS: 144092-31-9 Catalog Number: 10-4504 Activity: RARα antagonist Molecular Weight: 484.65 Molecular Formula: C28H36O5S Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 12 mg/ml with warming) Physical Properties: White solid Purity: 98% by TLCNMR (Conforms) Storage Temperature: -20° Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO