Vimentin

IFU Description: This monoclonal antibody recognizes vimentin, which is the main intermediate filament protein present in cells of mesenchymal origin. This antibody does not show cross-reactivity with other closely related intermediate filament proteins such as Desmin and GFAP. This marker has been shown to be helpful in labeling mesenchymal-derived tumors such as lymphomas, sarcomas, and melanomas. The expression of vimentin has also been suggested to be an indicator of tumor progression and potential for metastasis as a marker for epithelial-mesenchymal transition.  Catalog: VMAB004 Clone: CHMP029 Species Reactivity: Cat and Dog Source: Recombinant Rabbit Monoclonal Isotype: IgG Antigen: Vimentin Cellular Location: Cytoplasmic Positive Control: Sarcomas and Melanomas   References: Leader, M., Collins, M., Patel, J., and Henry K. Vimentin: an evaluation of its role as a tumour marker. Histopathology. 1987;11(1):63-72. [PMID: 2435649] Martin e las Mulas, J., Espinosa de los Monteros,