Papain-like Protease/ PLpro

Download Datasheet PLpro is a multifunctional cysteine protease that processes both viral polyprotein and some host-cell proteins (1). It is encoded within the Non-Structural protein 3. PLpro catalyzes the cleavages of N-terminus of the replicase polyprotein to release Nsp1, Nsp2 and Nsp3 and thus it plays a vital role for virus replication and infectivity. PLpro was also confirmed to be significant to antagonize the host's innate immunity (2). As an indispensable enzyme in the process of coronavirus replication and infection of the host (2). PLpro has been a popular target for drug developments to block virus assembly and amplification. 1.Báez-Santos YM, Mielech AM, Deng X, Baker S, Mesecar AD. Catalytic Function and Substrate Specificity of the Papain-Like Protease Domain of nsp3 from the Middle East Respiratory Syndrome Coronavirus. Journal of Virology 88(21), 12511–12527 (2014). 2.S.W. Li, C.Y. Wang, Y.J. Jou, S.H. Huang, L.H. Hsiao, L. Wan, et al. SARS coronavirus papain-like prot