Calm Down

Formula Purposes & Benefits Calm Down RX is formulated to support reduced anxiety, healthy sleep cycles (circadian rhythm), relaxation, reduce mental fatigue and improve mood. Our product is synthesized utilizing the latest scientific research and formulated with high quality ingredients. Our formula is third party independently tested for heavy metals, impurities, made in the USA, GMP certified, and produced in an FDA registered facility. 1% of the supplements on the market can match our world class standards.   Formula Ingredient Deck Benefits Of Each Ingredient  Calcium Carbonate   Supports bone health, muscle function, and cardiovascular health (36,37).   Regulates processes of bone resorption, mineralization, and fracture repair (36,37). Increases the effect of physical exercise on bone mineral acquisition in the period preceding puberty (36,37). Prevents the development of preeclampsia (36,37). Vitamin B1 Supports aerobic energy metabolism (oxidative phosphorylation), cell growth, optimal neuronal conduction (nerve impulses), and cardiovascular health (94). Supports cardiovascular function and aids as a neuroprotective agent in individuals with vitamin B-1 deficiencies (94, 95). Vitamin B2 Supports conversion and activation of other B vitamins, red blood cell production and serves as a cofactor for both glucose and fat metabolism (energy production) (92,93). Vitamin B5 Supports energy production, cell growth, cell repair, cognitive function, increased hippocampal volume (memory), and optimized bioenergetics (burning of carbohydrates, fat, and protein) (96). Vitamin B6 Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40). Reduces plasma glucose (blood sugar levels) via by inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39). Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40). May support blood sugar regulation in women with gestational diabetes (40). Cofactor for enzymes involved in DNA metabolism (40). Vitamin B3 (Niacin) Major B vitamin that supports cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9). Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9). Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9). Supports healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9). Prevents pathologies(diseases) such as Pellagra and reduces prevalence of nervous anorexia, cancer, and crohn's disease (10, 11). Supports sensitization of tumors to radiation via apoptosis (cell death) cascade of tumor mass and improves oxygen delivery to malignant tissues (cancer cells) (12). Supports cognitive health by reducing age-related decline of NAD+, increasing quinolinic acid and reducing neuroinflammation (9). Increased niacin associated NAD+ levels have been shown to increase neurotransmission, learning and memory (9). Niacin reduces the prevalence of neurodegenerative pathologies by preventing mitochondrial dysfunction (9). Biotin Supports conversion of food into cellular energy, hair health, skin health, and cognitive function (213,214). Enhances glucose breakdown into skeletal muscle tissue (213,214). Potassium Supports reduced blood pressure in hypertensive patients and improves hydration in individuals with low potassium levels (262). Magnesium Supports optimal nerve function, muscle contractions, cardiovascular, bone health, and decreased anxiety (90,91). Supports biological reactions such as ATP fueled reactions and pancreatic insulin secretion (90,91). Supports reduction systolic blood pressure, fasting glucose, triglycerides, and healthy HDL levels (90,91). Reduces peripheral cortisol levels in the CNS and supports relaxation and decreased anxiety (90,91). Zinc Supports immune function, skin health, cognitive function, and vision (172,173).  Supports stimulation of the innate and adaptive immune system (172,173). Supports the activation of lymphocytes and activation of innate and T cell mediated immunity (172,173). Supports cognitive function by modulation of neuronal signaling in areas of the brain associated with memory and learning (hippocampus) (172,173). Rhodiola   Lutein Carotenoid that supports vision health, immune health, cardiovascular health, and combats diabetic retinopathy (155,156). Supports increased lutein concentration in the macula and exhibits various features such as anti-inflammatory, anti-oxidative, and blue light-filtering effects (155,156). Supports visual health via increased lutein concentration in the macular layer of retina, reduced susceptibility to age related macular disease, reduced prevalence of cataracts, and improved plasma level of lutein and retinal macular pigment level (155,156). Chamomile Supports healthy sleep, relaxation, reduced anxiety, and antioxidant support (251,252,253). Supports antioxidant function due to high levels of quercetin (flavonoid antioxidant) (251,252,253). Supports sleep via increases in parasympathetic (relaxation mode) activity, increased benzodiazepine-like hypnotic activity (sleep inducer), and attachment to GABA receptors (251,252,253). Lemon Balm Supports healthy sleep, relaxation, reduced anxiety, and antioxidant support (254,255). Supports antioxidant function via ability to scavenge free radicals, reduce oxidative stress, increased glutathione production (master antioxidant) combat DNA damage (254,225). Supports relaxed sleep via enhanced REM cycles reduced stress at bedtime (254,225). Passion Flower Reduces stress, enhances sleep, and improved mood (248) Enhances positive mood and sleep via regulated gamma‐aminobutyric acid receptor A (GABAA) activity (receptor which controls sleep) (248). Hawthorn Berry Supports cardiovascular health and combats metabolic syndrome (165). Supports cardiovascular health via reduced atherosclerotic lesion areas, reduced cholesterol synthesis (acyl-coA-cholesterol acyltransferase enzyme), reduced very low-density lipoproteins (VLDL), and inhibited platelet aggregation (165). Munica Pruriens Supports blood sugar regulation, sexual enhancement, aids an anti-inflammatory agent, combats neurodegenerative disease, and supports antimicrobial activity (128). Supports anti-aging, rheumatoid, arthritis, diabetes, male infertility, and nervous disorders (128). Supports male sexual health via increased sperm motility and increased free testosterone (128). Combats neurodegenerative disease via stimulation of dopaminergic neurons (129). Supports blood sugar health via reduced blood glucose levels, improved insulin transport, and lowered H1AC levels (130). St. John’s Wort Combats depression and supports positive mood (249,250). GABA Supports relaxation, positive mood, increased memory, reduced anxiety, blood sugar regulation, and increased growth hormone production (102). Skullcap Supports calming mood and relaxation. L-Theanine Unique non-protein amino acid found in green tea (Camellia sinensis) (53). Supports mood, mental clarity, and cognitive health, memory, and is a natural anti-depressant/neuroprotective agent (53). Aids as an antidepressant due to partial antagonism for the N-methyl-D-aspartate receptor manifesting its cognitive optimizing effects (53). Reduces the neuropsychiatric side effects of chronic adolescent THC exposure (54). Ashwagandha Supports cardiovascular, hormonal, immune, healthy weight loss, mood, and optimized sleep (82,83). Reduces stress hormone cortisol resulting in improved body composition, sex hormone profile, and mood (82,83). Improves exercise performance via increased V02 max, muscular endurance, muscle hypertrophy (muscle growth), and decreased muscular fatigue (83). Improves quality of sleep by enhancing sleep recovery, reducing plasma cortisol concentrations, and enhancing REM sleep cycles (83). Supports hormonal and immune health via reduced production of inflammatory molecules (reactive oxygen species) and simultaneous increases in sex hormones (84). Bacopa Supports cognitive function, memory, alertness, and aids as an anti-stress agent (57). May combat inflammatory conditions such as asthma, bronchitis, dropsy, and rheumatism (56,59). Bacopa has been shown to have anti-inflammatory effects on macrophages (immune cells) and inhibits the release of IL-6 and TNF-α (inflammatory markers) from monocytes (immune cells) (58,59,). Promising candidate for the development of novel therapeutics that target neuroinflammation and have the potential for treating a wide range of CNS disorders including Alzheimer's disease, depression, and schizophrenia (59). Magnolia Supports antioxidant function, positive mood, and aids a neuroprotective agent (263,264). Supports relaxed shorten sleep latency and regulated gamma‐aminobutyric acid receptor A (GABAA) activity (receptor which controls sleep) (263,264). Griffonia Seed Ext -5-HTP Supports healthy sleep patterns, mood, reduced anxiety, and supports the gut brain axis (261). Supports healthy sleep patterns via enhanced circadian rhythm and increased natural melatonin production (261). Supports gut brain axis via natural increased production of serotonin (neurotransmitter) in gut neurons (260, 261). Valarian Root Reduces stress, enhances sleep, and improved mood (244,245). Enhances positive mood and sleep via regulated gamma‐aminobutyric acid receptor A (GABAA) activity (receptor which controls sleep) (244, 245).   Proper Use of This Supplement Suggested Use: As a dietary supplement take two (2) veggie capsules twice a day. For best results, take 20-30 minutes before a meal with an 8 oz glass of water, or as directed by your health care professional.   Our Formula Vs Other Formulas on the Market. 1. Uses third party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA registered facility. 1. Source cheap ingredients from heavily polluted soils. Even “organic” supplements not third party tested have been removed by FDA due to high levels of heavy metals. 2. Uses high quality nutraceuticals in an effective evidence based and efficaciously dosed formula. 2. Uses cheap sources of nutraceuticals that contain high amounts of fillers, heavy metals, and in formulated without evidence based dosages. Serving Size: 1 Capsules;Capsules Per Container: 60;Bottle Color: White;Bottle Size: 175cc;Lid Color: White * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.