cFluor^® BYG610 Anti-Human CD33 (WM53)

The WM53 monoclonal antibody binds to human CD33, a 67-kDa type I transmembrane glycoprotein in the immunoglobulin family. CD33, also known as Siglec-3, gp67, and p67, is expressed on monocytes, activated T cells, myeloid progenitors, granulocytes, dendritic cells, and mast cells. It is absent on erythrocytes, platelets, and lymphoid cells(1)(2). CD33 binds to sialic acids to act as a sialic acid-dependent cell adhesion molecule. It also contains intracellular tyrosine-based inhibition motifs (ITIMs), suggesting its function to inhibit cellular activity(3). The antibody was conjugated to a fluorophore and purified by chromatography. PRODUCT DETAILS Clone:                WM53 Reactivity:       Human Format:              cFluor® BYG6101 Isotype:               Mouse IgG1, κ Tested Dilution:  5 μL / test Application:        Flow Cytometry Storage:               2-8°C and protected from Light. Do not freeze Formulation:       Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide