cFluor^® UV610 anti-Human CD45RO (UCHL1)

The UCHL1 antibody reacts with the human CD45 isoform known as CD45RO, a 220-kDa protein tyrosine phosphatase. CD45 is one of the most abundant hematopoietic markers and is expressed on all leukocytes (leukocyte common antigen, LCA). Various isoforms are generated and expressed in cell-specific patterns. With their broad cell distribution, CD45 isoforms are critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, and others. The UCHL1 antibody is widely used as a marker for human CD45RO expression on thymocytes, activated memory T cells, monocytes, macrophages, and granulocytes. The antibody is reported to be cross-reactive for chimpanzee CD45RO.The antibody was purified by affinity chromatography and conjugated to the fluorophore. PRODUCT DETAILSClone: UCHL1Reactivity: HumanFormat: cFluor