cFluor® V450 Anti-Human CD16 (3G8)

The 3G8 monoclonal antibody binds to IgG receptor III (FcγRIII) that are in two forms: CD16a ((FcγRIIIA) and CD16b ((FcγRIIIB). With 95% sequence similarity, they are a conventional 50-65 kD polypeptide-anchored transmembrane protein and a 48 kD GPI-anchored protein, respectively. CD16a is expressed on NK cells and macrophages while CD16b is expressed on neutrophils (1)(2). CD16a also plays a crucial role for antibody-dependent cellular cytotoxicity (ADCC) by NK cells (3). The antibody was conjugated to a fluorophore and purified by affinity chromatography.   PRODUCT DETAILS Clone:                  3G8 Reactivity:          Human Format:                cFluor® V450 Isotype:               Mouse IgG1, κ Tested Dilution:  5 μL / test Application:        Flow Cytometry Storage:               2-8°C and protected from Light. Do not freeze Formulation:       Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% BSA (Origin USA) Data Sheets:       TDS SDS   RECOMMENDED USAG