Familial Intrahepatic Cholestasi Report

The Familial Intrahepatic Cholestasis test is based on Whole Genome Sequencing Test. As such, it analyzes all Common and Rare Variants associated with Familial Intrahepatic Cholestasis instead of a limited set of genes. Familial Intrahepatic Cholestasis is a disorder that causes progressive liver disease, which typically leads to liver failure. In people with Familial Intrahepatic Cholestasis, liver cells are less able to secrete a digestive fluid called bile. The buildup of bile in liver cells causes liver disease in affected individuals. Signs and symptoms typically begin in infancy and are related to bile buildup and liver disease. Specifically, affected individuals experience severe itching, yellowing of the skin and whites of the eyes (jaundice), failure to gain weight and grow at the expected rate (failure to thrive), high blood pressure in the vein that supplies blood to the liver (portal hypertension), and an enlarged liver and spleen (hepatosplenomegaly). Along with environmen