Osteoarthritis and rare cartilage diseases Report

The term osteoarthritis (OA) indicates a complex and heterogeneous set of pathological conditions affecting bones and cartilages. It is the most widespread musculoskeletal disease in the world, with a multifactorial etiology and able of affecting any joint, although the anatomical sites most affected are the hands, hips and knees. The main signs and symptoms of OA include pain, stiffness, reduction/loss of joint mobility and stability, swelling and muscle weakness.OA generally begins late in life as a result of the mixture of genetic and environmental factors, although there are some very rare types of osteoarthritis (and associated conditions) that are configured as monogenic disorders with early-onset and rapidly disabling.This is an area of ​​study that has not yet been explored but may contribute to a greater clinical understanding of OA.Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) is an autosomal recessive disease affecting tendons and bones, with pleural and p