Pendred Syndrome

Pendred Syndrome is the most common form of congenital bilateral deafness and is accompanied by euthyroid goiter (benign thyroid hypertrophy not associated with altered hormone levels). Transmitted with an autosomal recessive modality, in affected subjects it can also lead to the appearance of vestibular dysfunctions (the vestibular apparatus, located in the inner ear, allows to maintain the balance of the body especially during movements).The typical characteristic of Pendred Syndrome is the so-called Mondini malformation, given by the combination of widening of the vestibular aqueduct and deformity of the cochlea.The main mutations leading to Pendred Syndrome affect the functionality of pendrin, a protein expressed in the inner ear, breast, testes, kidney and thyroid. Hence the manifestations also affecting this gland, apparently far from the sensorineural deafness found in Pendred. This protein acts as a transporter of ions (including chloride and bicarbonate), giving rise to tissue