T InfectPlus (1000x)

T InfectPlus is a novel chemical cocktail that is formulated to enhance lentiviral and retroviral transduction efficiency in T cells. Combined with Fibronectin or Retronectin, T InfectPlus could dramatically improve the transduction efficiency in activated T cells. Protocols established with InfectPlus during process development are directly implementable for large-scale manufacturing of preclinical and clinical batches of viral vectors with the higher quality grades of T InfectPlus-premium   Example Data: Anti-Human B cells CD19 Antibody, clone FMC63 were subclone into the second generation (with CD28 for costimulatory factor) of CAR T in LVV vector for assay testing. T cells were activated by Dynabeads® Human T-Activator CD3/CD28 or TransAct  and tranduced by lentivirus in X-vivo 15 with 5% Human serum and IL7 (10ng/ml) +IL15 (5ng/ml).   Figure 1. Benefit of improved transduction and viability from T InfectPlus A:Significant improvement of transduction with T InfectPlus; B: No toxic