3D Printed Glioblastoma Multiforme

3D Printed Glioblastoma Multiforme Clinical HistoryA 56-year old male presented with a generalised seizure. He remained unconscious after this seizure and later died. A collateral history revealed 6 months of progressive confusion, short-term memory loss and personality change. PathologyCoronal sections of the brain post mortem show a 4cm necrotic and haemorrhagic tumour. Tumour invasion from the inferior frontal lobe into the lateral ventricle is apparent. Meningeal spread is evident on examination of the posterior aspect of the specimen. Further InformationGliomas are the second most common cancer of the central nervous system after meningiomas. The term “glioma” refers to tumours that are histologically similar to normal glial cells i.e. astrocytes, oligodendrocytes and ependymal cells. They arise from a progenitor cell that differentiates down one of the cell lines. Glioblastoma multiforme (GBM; also called glioblastoma) develop from the astr