How to Extract Small Unit Purified NRT Active For Quit-Smoking Aid Products

How to extract NRT for laboratory research purposes •    Weigh 10 g of the leaves in a beaker.•    Add 100ml NaOH solution and stir very well for 15 min.•    Filter in Buchner using glass wool and press the leaves very well by using another beaker.•    Transfer the leaves again to a beaker.•    Add 30ml DW and stir and filter again.•    Collect the filtrate together. (If there are any impurities, re-filter).•    Transfer the filtrate to the SF and extract by 25ml ether.•    Repeat the extraction 3 times.•    Gather the 4 filtrates in a conical flask.•    Dry by using 1 teaspoon anhydrous potassium carbonate.•    Filter.•    Evaporate ether in a water bath. (Avoid extra heat because nicotine is hydrolyzed by extreme heating).•    After the evaporation of ether, 4ml methanol was added to dissolve the resulting oil.•    Add 10 ml saturated picric acid solution.•    Cool in an ice bath to precipitate the nicotine di picrate crystals.•    Filter; allow drying and weighing the product.