Apo Transferrin Human, Native Protein (Serum)

Description Apo Transferrin Human, Native Protein (Serum) is a glycoprotein purified from human serum that has a molecular mass of approximately 77 kDa. It has a low iron content. Summary When not bound to iron, transferrin is known as "apotransferrin". When saturated with iron, transferrin is known as “holotransferrin”. Transferrin is the iron-transport protein of vertebrate serum and donates iron to cells through interaction with a specific membrane receptor, CD71. Transferrin appears to be indispensable for most cells growing in tissue culture. It is frequently referred to as a growth factor because, in analogy to other growth factor-receptor interactions, proliferating cells express high numbers of transferrin receptors, and the binding of transferrin to their receptors is needed for cells to initiate and maintain their DNA synthesis. Apart from its role as an iron transport protein, transferrin acts as a cytokine and has functions that may not be related to its iron-carrying capac