Fibroblast Growth Factor 23 (FGF-23) Human, E. coli Recombinant Protein

Description Our bioactive Fibroblast Growth Factor 23 (FGF-23) Human, E. coli Recombinant Protein is a single, non-glycosylated polypeptide chain that contains a total of 228 amino acids and has a 22.5 kDa molecular mass. The FGF-23 is purified by proprietary chromatographic techniques. Summary FGF-23 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-23 inhibits renal tubular phosphate transport. The FGF-23 gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of FGF-23 was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. FGF-23 mutations have als