Drugs that affect MTHFR and Methylation

Pharmaceutical Drugs are metabolized mostly via the CYP enzyme group.                        Many pharmaceutical drugs are depleting key nutrients that are required for methylation. These drugs may also alter epigenetic homeostasis by direct or indirect mechanisms. This may alter expression of receptors, signaling molecules and other proteins. With chronic exposure cells adapt and this can lead to a long term alteration of an epigenetic network. Epigenetic effects of pharmaceuticals may be involved in the etiology of many disorders that have a profound effect on our health. Did you know that hydralazine (a vasodilator) used to treat hypertension and procainamide (an antiarrythmic sodium channel blocker) inhibit DNA methyltransferase. Valproic acid (valproate), an anti epileptic and mood stabilizing drug targets demethylaiton activity to demethylate DNA. It affects our liver function and has an affect on genes associated with lipid, fatty acids and steroid metabolism. It affects the gli