Diclazuril, Levamisole, & Elevate Oral Powder

Diclazuril is a triazinone antiprotozoal that is effective for treating EPM. It is FDA-approved for use in horses not intended for food. Diclazuril is also used in treating infections caused by Isospora spp., Toxoplasma gondii, and Eimeria spp. and has been used for treating coccidiosis. Diclazuril exerts its anti-protozoan effect by inhibiting merozoite production. In horses, the oral absorption is 1.56% with a half-life of 43-65 hours. Other studies in horses have shown that at a dose of 1 mg/kg and 0.5 mg/kg the half-life is 55, and 87 hours, respectively, with peak concentration of 0.185 and 0.1 mcg/mL, respectively. Levamisole is a phenylimidazothiazole originally developed as an antihelminthic; it is now widely used as an immunostimulant and antineoplastic agent. Levamisole is effective against abomasal nematodes, small intestinal nematodes, large intestinal nematodes, and lungworms. Adult forms of species that are usually covered by levamisole include Haemonchus spp, Trichostron