AN2

Compound AN2 reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT). AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons. Product Name AN2 Synonyms 5,7-dihydroxy-4-phenylcoumarin CAS Number 7758-73-8 Related CAS Molecular Formula C15H10O4 Molecular Weight 254.241 SMILES OC1=CC(O)=C2C(OC(=O)C=C2C2=CC=CC=C2)=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO, DMF Shipping Conditions Room Temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only ReferencesLi, Z., Wang, C., Wang, Z., Zhu, C., Li, J., Sha, T., Ma, L., Gao, C., Yang, Y., Sun, Y., Wang, J., Sun, X., Lu, C., Difiglia, M., Mei, Y., Ding, C., Luo, S., Dang, Y., Ding, Y., … Lu, B. (2019). Allele-s