Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)

SOLU-KNEX® cleavable linker features a Val-Cit dipeptide. In this product, a Azide-Dap(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m-PEG4 is attached to the commonly used self-immolative para-aminobenzyl (PAB) moiety to further increase aqueous solubility. Derived from established ADC linker architectures, SOLU-KNEX® ADC linkers integrate solubilizing moieties—such as PEG, amine-containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned through selection and combination of these groups, making the linkers highly adaptable for diverse ADC and related applications. SOLU-KNEX® is a registered trademark of Tenova Pharmaceuticals, Inc. For research use only. Product Name Azide-Dap(m-PEG4)-Val