Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan
tenovapharma.com

Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan

$490.00
{{option.name}}: {{selected_options[option.position]}}
{{value_obj.value}}

Tenova Pharma

View Store

SOLU-KNEX® cleavable linker features a Val-Cit dipeptide. m-PEG8 is attached to the commonly used self-immolative para-aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase I–DNA complex, resulting in cell-cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU-KNEX® ADC linkers integrate solubilizing moieties—such as PEG, amine-containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned through selection and combination of these groups, making the linkers highly adaptable for diverse ADC and related applications. SOLU-KNEX® is a registered trademark of Tenova Pharmaceuticals, Inc. For research use only. Product Name Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan Synonyms CAS Number Related CAS Molecular Formula

Show More Show Less