14-3-3 ε (D238) Polyclonal Antibody-BS2177

14-3-3 ε (D238) Polyclonal Antibody Sizes: 50µl, 100µl Catalogue Numbers: BS2177-50, BS2177-100 Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Swiss-Prot: P62258 Host: Rabbit Reactivity: Human, Mouse, Rat Applications: WB, IHC, IF All Applications: WB: 1:500~1:1000 IHC: 1:50~1:200 IF: 1:50~1:200 Background: 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 β, γ, ε, ζ, η, θ and σ. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and im