14-3-3 sigma Polyclonal Antibody-BS90003

14-3-3 sigma Polyclonal Antibody Sizes: 50µl, 100µl Catalogue Numbers: BS90003-50, BS90003-100 Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 Swiss-Prot: P31947(Human) EntrezGene:313017(Rat) Host: Rabbit Reactivity: Human, Rat Applications: WB, IHC All Applications: WB:1:1,000 IHC:1:50-1:200 Background: 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine moti