Recombinant Human CD163 Protein

Product Overview Description Recombinant Human CD163 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Ser42-Ser1045. Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC Accession Q86VB7 Target Symbol CD163 Synonyms M130; CD163 molecule; CD163; GHI/61; HbSR; MM130; RM3/1; SCARI1; sCD163 Species Human Expression System HEK293 Tag C-His-Avi Expression Range Ser42-Ser1045 Mol. Weight The protein has a predicted MW of 111.4 kDa. Due to glycosylation, the protein migrates to 115-130 kDa based on Tris-Bis PAGE result. Form Lyophilized Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. Endotoxin Less than 1EU per ug by the LAL method. Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Shipping Shipped at ambient temperature. Gene Background The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-specific protein and the upregulated expression of this receptor is one of the major changes in the macrophage switch to alternative activated phenotypes in inflammation. Accordingly, a high CD163 expression in macrophages is a characteristic of tissues responding to inflammation.