Alexa Fluor® 488 anti-human CD40

CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis.PRODUCT DETAILSClone: 5C3Antibody Type: MonoclonalReactivity: Human, Cynomolgus, RhesusFormat: Alexa Fluor 488Host: MouseIsotype: IgG1, κApplications: FC - Quality testedRegulatory Status: RUOData Sheets: TDS | SDSNote to Purchaser: This product is manufactured and supplied by BioLegend, Inc. under an agreement between BioLe