Anti-Human Axl Monoclonal Antibody, Clone: Tilvestamab

  Anti-Human Axl Monoclonal Antibody, Clone: Tilvestamab Clone: Tilvestamab                          Catalog#: AB5310 Description: The AXL protein contains 894 amino acids and has a molecular weight of 104 kDa. It can be divided into extracellular domain, transmembrane domain, and intracellular domain. It belongs to type I transmembrane receptor and can produce a soluble extracellular fragment by proteolysis outside the transmembrane domain. The carboxy-terminal inside the cell is the kinase domain. AXL belongs to the TAM (TAM family also includes TYRO3/AXL/MER) family of receptor tyrosine kinases (RTKs). It is widely expressed in epithelial, mesenchymal, and hematopoietic cells. It is highly expressed in various cancers such as non-small cell lung cancer, breast cancer, and ovarian cancer. It is closely related to the occurrence, development, and drug resistance of tumors and has become a hot research topic today. Reactivities: Human Target: Axl Clone: Tilvestamab