Anti-Human CD159a Monoclonal Antibody, Clone: Monalizumab

  Anti-Human CD159a Monoclonal Antibody, Clone: Monalizumab Clone: Monalizumab                       Catalog#: AB5371 Description: The natural killer (NK) cell receptor family 2 (NKG2) includes NKG2A/B/C/D/E/F. Among them, NKG2A is an inhibitory receptor in the NKG2 receptor family, also known as killer cell lectin like receptor C1 (KLRC1), CD159a, and NK cell receptor A, which are one of the transmembrane proteins preferentially expressed on the surface of NK cells. NKG2A is mainly expressed on the surface of NK cells and some T cells (CD8+T cells, Th2 cells, and NKT cells). On the surface of human immune cells, NKG2A-CD94, a heterodimer complex formed by the connection of NKG2A and CD94 molecules (NK cell surface facial mask protein) in the form of disulfide bonds, is recognized by the non classical histocompatibility complex I (MHC I) class molecule HLA-E on the target cells. This molecule is low expression under normal conditions, but on the surface of most tumor cells, the express