Matrix Gla Protein (MGP) Human, E. coli Recombinant Protein

Description Matrix Gla Protein (MGP) Human, E. coli Recombinant Protein is a single, non-glycosylated polypeptide chain containing 98 amino acids (20-96) and has a molecular mass of 11.8 kDa. The MGP is fused to a 20 amino acid His-Tag at N-terminus and is purified by proprietary chromatographic techniques. Summary Matrix Gla protein (MGP) is a member of a family of vitamin-K2 dependent, Gla-containing proteins. MGP has a high affinity binding to calcium ions, similar to other Gla-containing proteins. The protein acts as an inhibitor of vascular mineralization and plays a role in bone organization. MGP is vital for the regulation of calcification in the extracellular matrix, particularly in cartilage and arteries. Other Names Matrix Gla protein, Cell growth-inhibiting gene 36 protein, GIG36, MGLAP, NTI. Application Notes A study by Nishimoto S. K. & Nishimoto M. concluded that "cells attach and spread better on fibronectin and MGP coated surfaces than to fibronectin alone, even