17-OH Progesterone (17-OHP) [LC/MS]

Diagnostic Blood Test: 17-OH Progesterone (LC/MS) The adrenal glands — small organs that sit on top of the kidneys — produce multiple hormones including 17-OH progesterone. Testing levels of this biomarker can provide information about the health of the adrenal glands and identify hormone imbalances that may lead to acne or infertility. Measuring 17-OHP levels in the blood is crucial for diagnosing and managing adrenal gland disorders, particularly congenital adrenal hyperplasia (CAH). Elevated levels of 17-OHP are commonly associated with CAH, a genetic condition that impairs cortisol production and leads to an overproduction of androgens, potentially causing abnormal physical development and hormonal imbalances. Conversely, abnormally low levels of 17-OHP may indicate adrenal insufficiency or other endocrine dysfunctions affecting hormone synthesis.