Cognition

Overview Transparent Labs Cognition is a high-performance, evidence-based nootropic supplement featuring four key ingredients that support healthy cognitive function: Rhodiolife® (Rhodiola rosea extract), Cognizin® (citicoline), SerinAid® (phosphatidylserine), and PurCaf® (organic caffeine). This formula also contains B vitamins, L-theanine, and huperzine-A to complement overall brain health.  So-called "brain supplements" are myriad nowadays, given the convincing evidence that cognitive and behavioural disturbances can be alleviated with not only prescription drugs but also natural ingredients. However, many brain health supplements lack evidence-based nootropics, instead relying on experimental compounds with questionable efficacy and safety. Our Cognition supplement includes patented and proven ingredients tested in human clinical trials for improving cognitive performance (e.g., working memory and mental alertness), brain function, stress resilience, mood, and more! And with just the right amount of caffeine, Cognition helps you dial in and focus without feeling overstimulated or jittery. Key Features Supports Cognitive Function and Mental Energy: Cognition is meticulously crafted with evidence-based ingredients such as Cognizin®, SerinAid®, and Rhodiolife® that work synergistically to fortify your mental performance and acuity starting with the very first dose. Improves Motivation and Drive: By controlling cortisol levels and supporting dopamine production, Cognition contributes to greater motivation and drive so you can conquer the day ahead. Enhance Stress-Resiliency and Mood: The adaptogens and nootropics in Cognition help the body and brain become more resilient to psychological and physical stressors, encouraging a balanced mood throughout the day. Stackable with Pre-Workout Formulas for Enhanced Focus: Cognition can be stacked with your favorite pre-workout supplement to bolster focus and drive during training. (Note that Cognition provides 100 mg of caffeine per serving, so take this into account when combining with caffeinated pre-workouts.) Third-Party Tested and Certified for Quality: As part of our commitment to industry-leading transparency and quality, every batch of Cognition is tested by a third-party lab for purity and potency. Active Ingredients and Benefits Rhodiolife® (Rhodiola rosea Root Extract, 5% Rosavins) | 600 mg Rhodiolife® is the world’s first standardized Rhodiola rosea extract to be made commercially available. This patented ingredient is developed by Nektium Pharma and is 100% identity guaranteed, ensuring authenticity and potency with 5% rosavins and 1.8% salidroside (the key beneficial constituents in Rhodiola). As a prestigious adaptogenic herb, Rhodiola rosea has been increasingly studied as a natural treatment for various mental health conditions (e.g., generalized anxiety disorder and moderate depression) with promising results [1]. The roots of Rhodiola rosea are enriched in numerous phytonutrients—notably rosavins and salidroside—that possess many putative health benefits, including: Improving cognitive deficiencies and depressive symptoms [2, 3] Enhancing the immune system [4] Promoting exercise performance [5, 6] Supporting healthy blood pressure levels and cerebral blood flow [7] Cognizin® Citicholine (CDP-Choline) | 250 mg Cognizin® is a patented form of choline known as citicoline, or cytidine diphosphate (CDP)-choline, the industry’s gold standard for choline supplementation. Choline is an essential B vitamin becoming increasingly scarce in the modern human diet [8]. It plays a vital role in acetylcholine synthesis, the primary neurotransmitter governing cognitive function and mental acuity when handling tasks that demand sharp focus and concentration. While you can find many nootropic supplements with choline, they almost always contain choline bitartrate, which has negligible impact on choline levels in the brain [9]. On the contrary, a recent human clinical trial found that subjects given a CDP-choline supplement experienced a two-fold increase in plasma levels of both choline and uridine for over 10 hours—this improved performance on mentally demanding tasks like memory tests and interpretation [10]. Moreover, choline and uridine work synergistically to synthesize phospholipid precursors that protect brain cells, thereby supporting neuronal function and integrity [11]. SerinAid® (70% Phosphatidylserine) | 200 mg SerinAid® is the purest and most potent phosphatidylserine ingredient on the market, derived exclusively from plant sources. Phosphatidylserine is an important phospholipid that protects neurons and glial cells in the brain and acts as a cellular signaling molecule to keep the mind sharp [11]. Recent research reviews contend phosphatidylserine supplementation may help alleviate mild cognitive impairment and improve memory [12, 13]. Further evidence shows phosphatidylserine administration attenuates stress-induced cortisol spikes, thus supporting mood and adrenal balance [14, 15]. PurCaf® Organic Caffeine (from Green Coffee Bean) | 100 mg While many nootropic supplements contain synthetic caffeine, we formulated Cognition with organic caffeine derived from green coffee beans (as PurCaf®). On the molecular level, caffeine (chemically known as 1,3,7-trimethylxanthine) is an alkaline, organic substance derived from xanthine — a biologically important purine base found in many bodily tissues and fluids. Methylxanthines like caffeine stimulate the central nervous system (CNS) and heart to promote wakefulness and motivation. Numerous studies have shown that taking caffeine can significantly improve overall cognitive performance and may even reduce the risk of neurodegenerative conditions [16, 17]. L-Theanine | 100 mg L-theanine is a green-tea-derived amino acid that readily traverses the blood-brain barrier to exert nootropic effects [18]. When combined with caffeine, L-theanine demonstrates many benefits for cognitive faculties, such as increasing reaction time, attention, and memory [19]. It also reduces jitters in caffeine-sensitive individuals and promotes relaxation without affecting wakefulness and energy [20] Huperzine-A (from Huperzia serrata Leaf Extract) | 300 mcg A powerful nootropic, huperzine-A is a naturally occurring alkaloid found primarily in the firmoss Huperzia serrata. It has long been revered for its ability to boost cognitive function. Research has shown that huperzine-A is a potent inhibitor of acetylcholinesterase, thereby prolonging the actions of acetylcholine [21]. This results in heightened mental acuity and a greater capacity to memorize and recall information. B Vitamin Complex (Vitamins B6, B9, and B12) B vitamins in Cognition are the key cofactors in synthesizing several neurotransmitters, including serotonin, gamma-aminobutyric acid (GABA), and dopamine. Clinical research has shown that regular B vitamin supplementation can help protect the brain from neurodegeneration and bolster mental performance, suggesting the role of these micronutrients in long-term brain health [22]. How To Use As a dietary supplement, take one serving (2 capsules) once daily with 6 to 8 fl. oz of water/liquid, preferably on an empty stomach. Optimal Consumption Times We recommend taking one serving mid-morning (between breakfast and lunch) to support cognitive function throughout the day. An additional serving may be taken in the late afternoon if you need help focusing throughout the evening. Note: This product contains 100 mg of natural caffeine per serving—avoid taking it within five hours of bedtime. FAQs What are the benefits of TL Cognition? The evidence-based benefits of the ingredients in this product include: Improving cognitive faculties (e.g., reasoning, focus/attention, and memory). Increasing perceived energy levels (i.e,. the “pep” you feel after ingesting caffeine). Enhancing mood and motivation so you can stay productive and tackle the day ahead. Supporting the body’s resiliency to stressful conditions. Will this product help with memory loss and age-related cognitive impairment? TL Cognition is formulated to support cognitive function and nourish brain cells with beneficial micronutrients, such as choline, phosphatidylserine, and rosavins. While randomized clinical trials in healthy adults suggest these nutrients may be useful for preventing cognitive decline and improving cognitive faculties, TL Cognition—like all dietary supplements—is not intended to treat, cure, or diagnose medical conditions. It's important to talk to your doctor if you're concerned about cognitive decline and/or your mental health. How do I tell if I'm at risk of Alzheimer's disease and other cognitive dysfunctions? Detecting cognitive decline in the early stages remains tricky from a clinical perspective. Still, it's important to check with your primary care physician or another qualified healthcare practitioner if you suspect something is off, as they can test for biomarkers in cerebrospinal fluid.