Fmoc-Val-Cit-PAB - CAS# 159858-22-7

Fmoc-Val-Cit-PAB-OH, CAS No. 159858-22-7, is a useful heterobifunational linker for making Antibody-Drug-Conjugates (ADC) for targeting drug delivery. The Val-Cit will specifically be cleaved by catepsin B. As this enzyme is only present in the lysosome, the ADC payload will only be released in the cell. The azido group will react with DBCO, BCN or other Alkyne group through click chemistry. The PEG spacer increases aqueous solubility.Product informationCAS Number: 159858-22-7Molecular Weight: 601.69Formula: C33H39N5O6Chemical Name: Fmoc-Val-Cit-PABSmiles: CC(C)[C@H](NC(=O)OCC1C2=CC=CC=C2C2=CC=CC=C21)C(=O)N[C@@H](CCCNC(N)=O)C(=O)NC1=CC=C(CO)C=C1InChiKey: DALMAZHDNFCDRP-VMPREFPWSA-NInChi: InChI=1S/C33H39N5O6/c1-20(2)29(38-33(43)44-19-27-25-10-5-3-8-23(25)24-9-4-6-11-26(24)27)31(41)37-28(12-7-17-35-32(34)42)30(40)36-22-15-13-21(18-39)14-16-22/h3-6,8-11,13-16,20,27-29,39H,7,12,17-19H2,1-2H3,(H,36,40)(H,37,41)(H,38,43)(H3,34,35,42)/t28-,29-/m0/s1Technical DataAppearance: Solid Power.Purity