(4R, 5S)-Nutlin carboxylic acid
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(4R, 5S)-Nutlin carboxylic acid

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(4R,5S)-Nutlin carboxylic acid (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. (4R,5S)-Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTACs.Product informationCAS Number: 2306390-08-7Molecular Weight: 639.53Formula: C32H32Cl2N4O6Synonym:MDM2 ligand 2E3 ligase Ligand 15Chemical Name: 2-{4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazole-1-carbonyl]-2-oxopiperazin-1-yl}acetic acidSmiles: CC(C)OC1=CC(=CC=C1C1=N[C@@H]([C@H](C2C=CC(Cl)=CC=2)N1C(=O)N1CC(=O)N(CC(O)=O)CC1)C1C=CC(Cl)=CC=1)OCInChiKey: CYFZSMNCDNFMOG-IHLOFXLRSA-NInChi: InChI=1S/C32H32Cl2N4O6/c1-19(2)44-26-16-24(43-3)12-13-25(26)31-35-29(20-4-8-22(33)9-5-20)30(21-6-10-23(34)11-7-21)38(31)32(42)37-15-14-36(18-28(40)41)27(39)17-37/h4-13,16,19,29-30H,14-15,17-18H2,1-3H3,(H,40,41)/t29-,30+/m1/s1Technical DataAppearance: Solid PowerPurity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Shipped under ambient temperature as non-

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