(3S, 4S)-PF-06459988
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(3S, 4S)-PF-06459988

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Xcess Biosciences

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(3S, 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less active. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 has excellent selectivity against EGFR wild-type while possessing a minimally reactive electrophile that reduces the propensity of off-target labeling.Product informationCAS Number: 1858291-14-1Molecular Weight: 431.88Formula: C19H22ClN7O3Chemical Name: 1-[(3S,4S)-3-[({5-chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl]prop-2-en-1-oneSmiles: CN1C=C(C=N1)NC1=NC(OC[C@@H]2CN(C[C@H]2OC)C(=O)C=C)=C2C(Cl)=CNC2=N1InChiKey: ODMXWZROLKITMS-SMDDNHRTSA-NInChi: InChI=1S/C19H22ClN7O3/c1-4-15(28)27-7-11(14(9-27)29-3)10-30-18-16-13(20)6-21-17(16)24-19(25-18)23-12-5-22-26(2)8-12/h4-6,8,11,14H,1,7,9-10H2,2-3H3,(H2,21,23,24,25)/t11-,14+/m0/s1Technical DataAppearance: Solid PowerPurity: ≥98% (or refer to the Certificate of Analysis)Shipping Condition: Ship

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