(32-Carbonyl)-RMC-5552
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(32-Carbonyl)-RMC-5552

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(32-Carbonyl)-RMC-5552 is a potent mTOR inhibitor. (32-Carbonyl)-RMC-5552 inhibits mTORC1 and mTORC2 substrate (p-P70S6K-(T389), p-4E-BP1-(T37/36), AND p-AKT1/2/3-(S473)) phosphorylation with pIC50s of > 9, >9 and between 8 and 9, respectively (patent WO2019212990A1, example 2).Product informationCAS Number: 2382768-55-8Molecular Weight: 879.96Formula: C42H57N9O12Chemical Name: (1R, 2R, 4S)-4-[(2R)-2-[(1R, 9S, 12S, 15R, 18R, 19R, 21R, 23S, 30S, 32S, 35R)-1, 18-dihydroxy-19, 30-dimethoxy-15, 17, 21, 23, 29, 35-hexamethyl-2, 3, 10, 14, 20-pentaoxo-11, 36-dioxa-4-azatricyclo[30.3.1.0, ]hexatriaconta-16, 24, 26, 28-tetraen-12-yl]propyl]-2-methoxycyclohexyl N-[27-(6-{[4-amino-3-(2-amino-1, 3-benzoxazol-5-yl)-1H-pyrazolo[3, 4-d]pyrimidin-1-yl]methyl}-1, 2, 3, 4-tetrahydroisoquinolin-2-yl)-27-oxo-3, 6, 9, 12, 15, 18, 21, 24-octaoxaheptacosan-1-yl]carbamateSmiles: NC1=NC2=CC(=CC=C2O1)C1=NN(CC2=CC3CCN(CC=3C=C2)C(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(O)=O)C2=NC=NC(N)=C12InChiKey: KFRKQPJGGQSJKC-

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