Biotinylated Human Nectin-4 Protein IgV Domain, His-Avi Tag

Nectin-4, also known as PVRL4 is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. The extracellular domain of human Nectin-4 shares 91%, 92%, 93%, 91% and 90% amino acid sequence homology with the corresponding regions of mouse, rat, canine, porcine and bovine Nectin-4, respectively. In many human ductal breast or non-small cell lung carcinomas, Nectin4 is upregulated. In forming adherens junctions, trans interactions of Nectin-4 initiate cell-cell interactions and recruit intracellular cadherins through afadin and other junctional proteins. These interactions organize the actin cytoskeleton, strengthen attachment to basement membrane and promote further cell-cell connections.   Specifications Synonyms EDSS1; LNIR; Nectin4; PRR4; NECTIN4; PVRL4 Uniprot No. Q96NY8-1 Source Recombinant Biotinylated Human Nectin-4 Protein IgV Domain is expressed from HEK293 Cells with His tag and Avi tag at the C-terminal. It contain