Biotinylated Human FGFR1 alpha (IIIc) Protein , His-Avi Tag

Fibroblast growth factors (FGFs) comprise a family of at least eighteen structurally related proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentiation, angiogenesis, wound healing and tumorgenesis. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Additional splicing events for FGF R1-3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF receptors with alternative IgIII domains (IIIb and IIIc).  Mutations in FGF R1-3 have been found in patients with birth defects involving craniosynostosis.   Specifications Synonyms FGF R1a; FGFR1 alpha Uniprot No. P11362.7 Source Recombinant Biotinylated Human FGFR1 alpha (IIIc)