Endostatin Human Recombinant Protein

Description Our bioactive Endostatin Human Recombinant Protein, produced in E. coli, is a single, non-glycosylated, polypeptide with a predicted molecular mass of 20 kDa. The Endostatin is purified by proprietary chromatographic techniques. Summary Collagen XVIII is an important extracellular matrix component that is expressed in basement membranes. Degradation of Type XVIII collagen results in the generation of endostatin (ES), a 20-kDa C-terminal fragment. Endostatin has been shown to act as a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo. Endostatin induces tyrosine phosphorylation of Shc (SH2 domain adapter protein) leading to specific inhibition in endothelial cell proliferation. Once a cluster of cancer cells reaches a diameter of about 1–2 mm, it must develop a blood supply in order to grow larger as diffusion is no longer adequate to supply the cancerous cells with oxygen and nutrients and to remove wastes. Therefore, these cells secrete substances tha