Gonadotropin-Releasing Hormone (GnRH) Human, E. coli Recombinant

Description Gonadotropin-Releasing Hormone (GnRH) Human, E. coli Recombinant, also known as Luteinizing-hormone releasing hormone (LHRH), is a non-glycosylated polypeptide chain containing 92 amino acids (24-92 a.a.) and has a molecular mass of 10.3 kDa. GnRH is fused to a 23 amino acid His-tag at N-terminus and is purified by proprietary chromatographic techniques. Summary GnRH is a peptide hormone responsible for the release of FSH and LH from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.  At the pituitary, GnRH stimulates the synthesis and secretion of the follicle-stimulating hormone (FSH) and luteinizing hormone (LH). These processes are controlled by the size and frequency of GnRH pulses, as well as by feedback from androgens and estrogens. Low frequency GnRH pulses lead to FSH release, whereas high frequency GnRH pulses stimulate LH release. There are differences in GnRH secretion between males and females. In males, GnRH is secreted in pulses at