LR3 IGF-I Human, E. coli Recombinant Protein

Description Our bioactive LR3 IGF-I Human, E. coli Recombinant Protein is a single, non-glycosylated, polypeptide chain that contains 83 amino acids and has a 9.1 kDa molecular mass. LR3 IGF-I is a long-term analog of human IGF-I, specifically designed and manufactured for mammalian cell culture. In LR3 IGF-I there is an arginine substitution for the third position glutamic acid and a 13 amino acid N-terminal peptide extension, which is derived from methionyl porcine Growth Hormone. As a result of these modifications, LR3 IGF-1 has a reduced affinity for IGFBPs, a longer half-life, and higher biological potency compared to wildtype IGF-1.  Summary IGF-1 (Insulin-like growth factor-1) is a major hormonal mediator of statural growth. Under regular circumstances, GH (growth hormone) binds to its receptor in the liver, and other tissues, and stimulates the synthesis/secretion of IGF-1. In target tissues, the Type 1 IGF receptor, that is homologous to the insulin receptor, is activated by