IGF-I Human, E. coli Recombinant Protein

Description Our bioactive IGF-I Human, E. coli Recombinant Protein is a single, non-glycosylated, polypeptide chain that contains 70 amino acids and has a 7.6 kDa molecular mass. IGF-1 is purified by proprietary chromatographic techniques. Summary IGF-1 (Insulin-like growth factor-1) is a major hormonal mediator of statural growth. Under regular circumstances, GH (growth hormone) binds to its receptor in the liver, and other tissues, and stimulates the synthesis/secretion of IGF-1. In target tissues, the Type 1 IGF receptor, that is homologous to the insulin receptor, is activated by IGF-1, leading to intracellular signaling which stimulates multiple processes leading to statural growth. IGF-1 metabolic actions are partly directed at stimulating the uptake of glucose, fatty acids, and amino acids so that metabolism supports growing tissues. IGF-I is commonly used as a media supplement in human pluripotent stem cell culture and is needed for cell growth in the absence of insulin. IGF-I