ACC1, Monoclonal Antibody, 100ug

This antibody binds ACC1 to the citrullinated triple-helical collagen type II (CII) epitope (position 359-369), the C1 epitope. The ACC1 antibody recognizes the second citrulline at position 365 in mouse Collagen Type II. The antibody binds to flexible triple-helical Collagen Type II determinants and many citrullinated CII peptides and was found to cross-react with several non-citrullinated epitopes on native Collagen Type II. It cross-reacts with mouse and human. Citrullination of proteins is a post-translational modification in which arginine is converted into citrulline by a family of enzymes called peptidylarginine deiminases (PADs). Proteins are susceptible to citrullination during inflammatory processes, and an autoantibody response to citrullinated proteins is a hallmark of Rheumatoid Arthritis. Synonyms:COL2A1, Collagen Type II, Collagen alpha-1(II) chain, CII, Col II, citrullinated CII; citrullinated Col II; citrullinated proteins.   The Mouse Anti-citrullinated COL2A