ACC4 (IgG1), Monoclonal Antibody, 100ug

This antibody is an anti-citrullinated protein antibody (ACPA) that, on Collagen alpha-1 (II) chain, binds specifically to citrullinated C1 epitope on alpha-chain (position 359–369). It cross-reacts with mouse, bovine, and potentially human. Citrullination of proteins is a post-translational modification in which arginine is converted into citrulline by a family of enzymes called peptidylarginine deiminases (PADs). Proteins are susceptible to citrullination during inflammatory processes, and an autoantibody response to citrullinated proteins is a hallmark of Rheumatoid Arthritis. Synonyms:COL2A1, Collagen Type II, Collagen alpha-1(II) chain, CII, Col II, citrullinated CII; citrullinated Col II; citrullinated proteins.   The mouse Anti-citrullinated COL2A1 Antibody clone ACC4 binds to the C1 epitope on alpha-chain of collagen II when the first arginine in the epitope (position 359–369; is citrullinated (Cit- Arg). The antibody does not bind to the C1 epitope when the second arg