Uromodulin Glycoprotein (UMOD, Tamm-Horsfall Glycoprotein, THP) ELISA

The Uromodulin Glycoprotein ELISA kit is a 96-Well enzyme-linked immunosorbent assay used for the quantitative determination of Uromodulin Glycoprotein (THP) in urine, serum and plasma samples.  Uromodulin glycoprotein (also known as Tamm-Horsfall Glycoprotein, THP) is the most abundant protein found in the urine of mammals (2, 4). Uromodulin is 616 amino acids in length with a molecular weight of 80 kDa, and is synthesized in the thick ascending loop of Henle (3, 4). While the specific function of Uromodulin is unknown, it appears to have a role in the regulation of salt and water excretion by the kidney (3). Soluble Uromodulin has been found to help protect against urinary tract infections of E. coli and P. mirabilis by inhibiting the binding of the bacteria to the epithelial cells of the urinary tract (1, 6, 8). In addition, it has been suggested that Uromodulin may help prevent renal stone formation (7). Defects in Uromodulin are associated with human diseases such as familial juve