PD-L1 (CD274) Recombinant Protein, Human, 10ug

The human Programmed cell death 1 ligand 1 (PD-L1) / CD274 is a recombinant protein consists of a single glycosylated polypeptide chain with 245 amino acids (19-238aa). The programmed death-1 receptor (PD-1) and its ligands PD-L1 and PD-L2 are central components of immune checkpoint mechanisms in cancer and are key targets for immunotherapy. PD-1, a transmembrane receptor found on various immune cells such as activated T cells, Tregs, B cells, NK cells, and myeloid cells, interacts with PD-L1 and PD-L2, which are expressed on a wide range of cells. This interaction plays a crucial role in immune regulation by promoting cell death. Blocking the PD-1/PD-L1 pathway has demonstrated enhanced anti-tumor responses in cancers like pancreatic carcinoma, melanoma, and colon carcinoma. Combining PD-1 blockade with CTLA-4 antibody treatments has led to significant tumor regression in many patients. The critical role of PD-1 in modulating immune responses within the tumor microenvironment hi