T1/ST2 (IL-33 R) Monoclonal Antibody, azide-free, 0.5 mL

Mouse T1/ST2 (IL-33 R) monoclonal antibody (Clone DJ8, Host / Isotype Subclass: Rat IgG1, light chain not isotyped), azide-free,  for the identification and purification of murine T helper 2 (Th2) cells and all forms of murine mast cells. T1/ST2 (also known as IL-1 R4 or IL-33Ra) is a transmembrane glycoprotein expressed on mast cells and Th2 cells. It is a selective marker for both murine and human Th2 lymphocytes and plays a role in regulating inflammatory responses. IL-33 is a recently identified member of the IL-1 family of cytokines and is involved in Th2 mediated immune responses. IL-33 mediates its biological effects via T1/ST2 binding. The roles of IL-33 and T1/ST2 (IL-33Ra) have been investigated in many immune responses such as allergy, asthma, rheumatoid arthritis and osteoarthritis. References/Citations: Yan, C., Kuang, W., Ma, G., Guo, F., Jin, L., Wan, H., ... & Wang, L. (2025). E3 ligase RNF128 restricts A. alternata-induced ILC2 activation and type 2 immune response